Magnesium can do so much that it makes people skeptical that one simple mineral can be crucial for so many activities in the body. After all, magnesium is necessary in over 325 enzyme systems in the body that control thousands of chemical interactions.
We know that magnesium is necessary for bone health but it has a much broader scope than that. Most people think that calcium is the most important factor in bone health. Some are now realising that vitamin D is also a necessary component. However, it's not well known that magnesium is necessary to convert vitamin D into its active form so that it can turn on calcium absorption.
It turns out that all the enzymes metabolising vitamin D require magnesium as a necessary co-factor. When you take high doses of Vitamin D and if you are already low in magnesium, the increased amount of metabolic work drains magnesium from its muscle storage sites. That's probably why muscles are the first to suffer magnesium deficiency symptoms -- twitching, leg cramps, restless legs and charlie horses. Angina and even heart attacks affecting the heart muscle are all magnesium deficiency symptoms.
What about calcium? Magnesium stimulates the hormone calcitonin, which helps to preserve bone structure by drawing calcium out of the blood and soft tissues back into the bones. This action helps lower the likelihood of osteoporosis, some forms of arthritis, heart attack and kidney stones. So, if you're taking lots of calcium and not much magnesium, you are susceptible to these conditions.
The effectiveness and benefits of calcium in preventing and treating osteoporosis are enormously impaired in the absence of adequate levels of magnesium. Magnesium keeps calcium dissolved in the blood. Too much calcium along with too little magnesium can cause some forms of arthritis, kidney stones, osteoporosis and calcification of the arteries, leading to heart attack and cardiovascular disease. So, it's not just the calcium causing these problems but an associated lack of magnesium.
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Source: Huffington Post